Custom Synthesis Roadmap

The process of custom synthesis of a compound through the Biomaterials Platform consists of a number of steps, which will be iterated through for every compound:


  1. Input from partner (biological/medical)

Custom synthesis starts with a request for a material with certain properties, that belong to an application.


  1. Design of material/compound

In consultation with the Biomaterials Platform, the material type, and the required properties are translated to a definition of the material/compound.


  1. Synthesis scheme development

Synthesis of the compound requires optimization of reaction schemes, which includes characterization of the products via e.g. 1H-NMR spectroscopy, LC-MS, IR, GPC.


  1. Synthesis of compound

When the synthesis scheme is optimized, the compound can be produced on a substantial scale, which allows for further processing and characterization.


  1. Material characterization

Material properties such as thermal behavior (GPC), mechanical properties (tensile testing) can be characterized


  1. Biological characterization

Preliminary biological characterization can include biocompatibility and toxicity, assays and determination of cell-adhesive properties.


  1. Extensive (biological) characterization by requesting partner

Now the material/compound can be extensively characterized with respect to the required application by the partner involved.


  1. Adjustments to material/compound design

If changes need to made to the material/compound design, following from the characterization, the cycle can start again based on the first compound, or a new compound can be made.