The process of custom synthesis of a compound through the Biomaterials Platform consists of a number of steps, which will be iterated through for every compound:
- Input from partner (biological/medical)
Custom synthesis starts with a request for a material with certain properties, that belong to an application.
- Design of material/compound
In consultation with the Biomaterials Platform, the material type, and the required properties are translated to a definition of the material/compound.
- Synthesis scheme development
Synthesis of the compound requires optimization of reaction schemes, which includes characterization of the products via e.g. 1H-NMR spectroscopy, LC-MS, IR, GPC.
- Synthesis of compound
When the synthesis scheme is optimized, the compound can be produced on a substantial scale, which allows for further processing and characterization.
- Material characterization
Material properties such as thermal behavior (GPC), mechanical properties (tensile testing) can be characterized
- Biological characterization
Preliminary biological characterization can include biocompatibility and toxicity, assays and determination of cell-adhesive properties.
- Extensive (biological) characterization by requesting partner
Now the material/compound can be extensively characterized with respect to the required application by the partner involved.
- Adjustments to material/compound design
If changes need to made to the material/compound design, following from the characterization, the cycle can start again based on the first compound, or a new compound can be made.