Materials science (8SC00)
The use and understanding of materials and their mechanical properties is very important to be able to ultimately design a material for a certain (biomedical) application. This course describes the mechanical properties of various materials, and introduces the student to the micro-meso-macro model and the relation between structure and mechanical properties. Crystalline materials are described (including crystal lattices and structures). The effect of dislocations on the mechanical properties and the Griffith model of fracture are discussed. Several synthetic and biopolymers are described as well as their mechanical properties. Additionally composite materials are explained.
Interactions between (synthetic) biomaterials and tissues play a key role when a part of the body is replaced by an implant. At the surface of these implants (e.g. stents, sutures, hip prostheses, heart valves, blood vessels) molecular and microscopic processes determine their fate, so whether the implants ultimately fail or are successful. This course introduces the student to different classes of biomaterials and shows which processes play a role at the molecular level at the biomaterial-tissue interface.
Cell biological techniques and cell-biomaterial interactions (8MM20)
Techniques to modify cells (and tissues) are standard practice in the field of regenerative medicine and tissue engineering. Cellular engineering is used to monitor and modify processes. During this course various techniques are addressed to modify cells and to detect this. Proteins are modified and followed; from transcription until production. Importantly, in the field of regenerative medicine biomaterials play an eminent role, therefore you are introduced to the influence of materials on cell behavior. The main goal of this course is to learn and perform various cell culturing and cell analysis techniques.